Journal Article
The transcriptome of the olm provides insights into its evolution and gene expression
Holtze, S., Demirtürk, D., Ohlenschläger, O., Hegele, S., Siniuk, K., Förste, S., Raghavan, V., Groth, M., Bens, M., Hassel, N., Martel, A., Lukač, M., Cizelj, I., Fischer, M., Liu, H.
Record Number:
7006
Year:
2025
Journal:
Scientific Reports
Pages:
1-13
Volume:
15:28324
Notes:
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit
Abstract:
The olm (Proteus anguinus), with a predicted maximum lifespan of more than 100 years, is the longestlived amphibian, which in addition possesses a range of unique adaptations to its dark, subterranean cave habitat. To assess the underlying molecular signatures, we present the first comprehensive transcriptome of the olm. Our study provides gene expression data across six organs and comparative genomics analyses, accessible via an interactive web server: http://comp-pheno.de/olm. The data uncover significant organ-specific gene expression, with the brain showing the highest number of organ-specific expressed genes. Our findings reveal significantly more genes under strong negative selection than positive selection, particularly in brain-specific expressed genes. Processes under positive selection in the olm resemble those in other long-lived species
Times Cited:
6
Relevent Species:
Proteus parkelj Sket and Arntzen 1994Proteus undescribed species lineage Para-Littoral [Recknagel, Zaksek, Delic, Goricki and Trontelj 2023]Proteus undescribed species lineage Istra [Recknagel, Zaksek, Delic, Goricki and Trontelj 2023]Proteus undescribed species lineage Krajina [Recknagel, Zaksek, Delic, Goricki and Trontelj 2023]Proteus undescribed species lineage Kras/Carso [Recknagel, Zaksek, Delic, Goricki and Trontelj 2023]Proteus anguinus Laurenti 1768