Journal Article

The cavefish Triplophysa rosa has a well-developed adaptive immune system: Evidence from histological and comparative genomic analysis

Ni, L., Jin, L., Zeng, M., Xu, Y., Wang, Y. and Peng, Z.

Record Number:
6318
Year:
2024
Journal:
Aquaculture
Pages:
1-16
Volume:
581 740395
Abstract:
The long-term impact of limited and species-specific antigen exposure on immune system evolution is not well understood. Herein, we conducted histological and comparative genomic analyses using the cavefish Triplophysa rosa in order to investigate how restricted antigen exposure influences the evolutionary path of the vertebrate immune system. The histology and cellular characteristics of mucosa-associated lymphoid tissues (gills, skin, and intestines) and the major immune organs (spleen, head kidney, and thymus) of T. rosa were systematically investigated. Histological studies showed that T. rosa had intact immune organs (tissues) and a well-developed adaptive immune system. Our findings suggested that the immune system might have evolved due to the nondegradation of the thymus, which may be an adaptation to the cave environment. A comparative genomic analysis of T. rosa and surface fish was carried out to explore the evolutionary adaptiveness of their immune systems and the potential genomic changes arising from thymus non-degeneration. The analysis revealed that T. rosa developed an efficient adaptive immune system due to the expansion of genes related to T-cell activation and differentiation, consistent with the histological results. Achievement of well-developed adaptive immunity through a limited number of fixed antigens in a cave environment could confer long-term protection against pathogens, highlighting it as a beneficial survival strategy for cavefish. Our findings could provide new ideas for further research on immunity in cavefish.
Times Cited:
1
Related Records:
Wu, He and Li (2005)
Linemacheilus wulong
Chen, X.Y. and Yang, J. (2005)
Triplophysa rosa sp. nov.: A new blind loach from China
Wu, Q., He, L.J., Zhen, S.M. and Li, L.G. (2007)
White bubble blind fish - Wulong Li rod-shaped loach Heminoemacheilus wulongensis
Wang, J.J., Tang, Q.Y., Wang, Z.J., Zhang, Y.G., Wu, Q. and Peng, Z.G. (2012)
The complete mitogenome sequence of a cave loach Triplophysa rosa (Telestei, Balitoridae, Nemacheilinae)
Kottelat, M. (2012)
Draconectes narinosus, a new genus and species of cave fish from an island of Halong Bay, Vietnam (Teleostei: Nemacheilidae).
Huang, J. (2012)
Comparative studies on the gross anatomy and histological structure of the central nervous system between. In: Triplophysa bleekeri and Triplophysa rosa
Zhao, J., Zhao, K. and Peng, Z. (2014)
Development and characterization of eleven microsatellite markers for an endangered cavefish (Triplophysa rosa Chen and Yang, 2005) using 454 sequencing
Zhang, C.G. and Zhou, Y.H. (2016)
Species diversity and distribution of inland fishes in China
Niu, Y., Zhao, Q., Zhao, H., Ludwig, A. and Peng, Z. (2016)
Karyotype and genome size of an endangered cavefish (Triplophysa rosa Chen & Yang, 2005)
Wang, Y., Shen, Y., Feng, C., Zhao, K., Song, Z., Zhang, Y., Yang, L. and He, S. (2016)
Mitogenomic perspectives on the origin of Tibetan loaches and their adaptation to high altitude
Li, J.X. Wang, Y., Jina H.F.,Li, W.J., Yan, C.C., Yan, P.F., Zhang, X.Y., He, S.P. and Song, Z.B. (2017)
Identification of Triplophysa species from the Qinghai-Tibetan Plateau (QTP) and its adjacent regions through DNA barcodes
Liu, S., Ludwig, A. and Peng, Z. (2017)
Nine novel microsatellites for the cavefish (Triplophysa rosa Chen)
Niu, Y. (2017)
Comparative histological study of visual organs between Triplophysa rosa and Triplophysa bleekeri
Xiao, Y. (2017)
Genetic basis of the albinism in the cavefish Triplophysa rosa
Zhang, Y., Wang, Z., Zhang, Z., Wu, M.. Chen, J. and Zhao, Y. (2018)
The complete mitochondrial genome of Triplophysa brevibarba with phylogenetic consideration
Shi, C., Yao, M., Lv, X., Zhao, Q., Peng, Z. and Luo, Y. (2018)
Body and organ metabolic rates of a cave fish, Triplophysa rosa: influence of light and ontogenetic variation
Wu, W.J., He, A.Y., Yang, J.X. and Du, L.N. (2018)
Description of a new species of Triplophysa (Teleostei: Nemacheilidae) from Guizhou Province, China
Yang, X., Liu, H., Ma, Z., Zou, Y., Zou, M., Mao, Y., Li, X., Wang, H., Chen, T.,Wang, W. and Yang, R. (2019)
Chromosome‐level genome assembly of Triplophysa tibetana, a fish adapted to the harsh high‐altitude environment of the Tibetan Plateau
Sgouros, K., Page, L.M., Orlofske, S.A. and Jadin, R.C. (2019)
A revised molecular phylogeny reveals polyphyly in Schistura (Teleostei: Cypriniformes: Nemacheilidae)
Zhao, Q., Zhang, R., Xiao, Y., Niu, Y., Shao, F., Li, Y. and Peng, Z. (2020)
Comparative transcriptome profiling of the loaches Triplophysa bleekeri and Triplophysa rosa reveals potential mechanisms of eye degeneration
Wang, Y., Xiao, N., Wang, S., Luo, T., Yang, X., Liu, T. and Zhou, J. (2021)
The complete mitochondrial genome of a cavedwelling loach Triplophysa baotianensis (Teleostei:Nemacheilidae)
Chen, S., Sheraliev, B., Shu, L. and Peng, Z. (2021)
Triplophysa wulongensis, a new species of cave-dwelling loach (Teleostei, Nemacheilidae) from Chongqing, Southwest China
Zhao, Q., Shao, F., Li, Y., Yi, S.V. and Peng, Z. (2022)
Novel genome sequence of Chinese cavefish (Triplophysa rosa) reveals pervasive relaxation of natural selection in cavefish genomes
He, Y. and He, D.K. (2023)
X-ray microtomography study of cranium, pectoral fin and girdle, and Weberian Apparatus development in juvenile Triplophysa stewarti (Nemacheilidae)
Zhang, J.H., Long, R., Jing, Y.Y., Zhang, P., Xu, Y., Xiong, W., Zhu, Y.Q. and Luo, Y.P. (2023)
Loss of behavioral stress response in blind cavefish reduces energy expenditure
Xu, Y., Jing, Y., Zhou, J., Long, R., Meng, J. Yang, Y. and Luo, Y. (2023)
Age, growth, and energy storage of the cavefish Triplophysa rosa
Xu, Y., Jing, Y., Zhou, J., Long, R., Meng, J. Yang, Y. and Luo, Y. (2023)
Age, growth, and energy storage of the subterranean fish Triplophysa rosa (Cypriniformes: Nemacheilidae) from Chongqing, China
Ni, L., Jin, L., Zeng, M., Xu, Y., Wang, Y. and Peng, Z. (2024)
The cavefish Triplophysa rosa has a well-developed adaptive immune system: Evidence from histological and comparative genomic analysis