Journal Article

A local duplication of the Melanocortin receptor 1 locus in Astyanax

Gross, J.B., Weagley, J., Stahl, B.A., Ma, L., Espinasa, L. and McGaugh, S.E.

Record Number:
3939
Year:
2018
Journal:
Genome
Pages:
254-265
Volume:
61
Abstract:
In this study, we report evidence of a novel duplication of Melanocortin receptor 1 (Mc1r) in the cavefish genome. This locus was discovered following the observation of excessive allelic diversity in a ~820 bp fragment of Mc1r amplified via degenerate PCR from a natural population of Astyanax aeneus fish from Guerrero, Mexico. The cavefish genome reveals the presence of two closely related Mc1r open reading frames separated by a 1.46 kb intergenic region. One open reading frame corresponds to the previously reported Mc1r receptor, and the other open reading frame (duplicate copy) is 975 bp in length, encoding a receptor of 325 amino acids. Sequence similarity analyses position both copies in the syntenic region of the single Mc1r locus in 16 representative craniate genomes spanning bony fish (including Astyanax) to mammals, suggesting we discovered tandem duplicates of this important gene. The two Mc1r copies share ~89% sequence similarity, and, within Astyanax, are more similar to one another compared to other melanocortin family members. Future studies will inform the precise functional significance of the duplicated Mc1r locus, and if this novel copy number variant may have adaptive significance for the Astyanax lineage.
Times Cited:
1
Related Records:
Hubbs, C.L. and Innes, W.T. (1936)Bridges, W. (1940)Gresser, E. B. and Breder, C. M. (1940)Breder, C. M. and Gresser, E. B. (1941)Breder, C. M. and Gresser, E. B. (1941)Breder, C. M. and Gresser, E. B. (1941)Breder, C. M. (1942)Osorio Tafall, B. F. (1943)Breder, C. M. (1943)Breder, C. M. (1943)Breder, C. M. (1944)Alvarez, J. (1946)Breder, C. M. and Rasquin, P. (1947)Breder, C. M. and Rasquin, P. (1947)Schlagel, S. R. and Breder, C. M. (1947)Alvarez, J. (1947)Rasquin, P. (1949)Luling, K. H. (1953)Luling, K. H. (1953)Luling, K. H. (1953)Thines, G. (1954)Luling, K. H. (1954)Luling, K. H. (1954)Stefanelli, A. (1954)Rasquin, P. and Rosenbloom, L. (1954)Stefanelli, A. (1954)Luling, K. H. (1955)Luling, K. H. (1955)Sadoglu, P. (1956)Sadoglu, P. (1957)Sadoglu, P. (1957)Thines, G. and Kahling, J. (1957)Cahn, P. H. (1958)Grobbel, G. and Hahn, G. (1958)Kahling, J. (1961)Luling, K. H. (1962)Burgers, A. C. J., Bennink, P. J. H. and van Oordt, G. J. (1963)Franck, A. (1964)Thines, G., Wolff-Van Ermengem, F., Boucquey, C. and Soffie, M. (1965)Boucquey, C., Thines, G. and Van Der Borght, C. (1965)Thines, G., Soffie, M. and Vandenbussche, E. (1966)Peters, N. and Peters, G. (1966)Carmignani, M. P. A. (1966)Cavicchioli, G. and Guarnieri, P. (1966)Reed, M. (1966)Sadoglu, P. (1967)Schemmel, C. (1967)Walters, V. and Liu, R. K. (1967)Pfeiffer, W. (1967)Pfeiffer, W. (1967)Popper, A. N. and Tavolga, W. N. (1967)Carmignani, M. P. A. (1968)Wilkens, H. (1968)Mattheij, J. A. (1968)Mattheij, J. A. (1968)Sadoglu, P. and McKee, A. (1969)Weiss, B. A. (1969)Mattheij, J. A. (1969)Mattheij, J. A. and Sprangers, J. A. P. (1969)Gertychowa, R. (1970)Gertychowa, R. (1970)Weiss, B. and Martini, J. (1970)Popper, A. N. (1970)Whitt, G. S. and Maeda, F. S. (1970)Wilkens, H. (1970)Wilkens, H. (1970)Wilkens, H. (1970)Mattheij, J. A. (1970)Mattheij, J. A. (1970)Gertychowa, R. (1971)Popper, A. N. (1971)Wiley, S. and Mitchell, R. W. (1971)Wiley, S. and Mitchell, R. W. (1971)Zaccone, G. (1971)Wilkens, H. (1971)Thines, G. and Wissocq, N. (1972)Wilkens, H. and Burns, R. J. (1972)Avise, J. C. and Selander, R. K. (1972)Zaccone, G. (1972)Wilkens, H. (1972)Wilkens, H. (1972)Wilkens, H. (1972)Thines, G. and LeGrain, J. M. (1973)Voneida, T. J. (1973)Schemmel, C. (1973)Yasuda, K. (1973)Zeitlin, S. M. (1973)Durand, J. P. (1973)Zeitlin, S. M. and McDevitt, D. S. (1973)Mitchell, R. W. (1973)Schemmel, C. (1974)Schemmel, C. (1974)Chakraborty, R. and Nei, M. (1974)Sligar, C. (1974)Omura, Y. (1975)Sadoglu, P. (1975)Peters, N., Scholl, A. and Wilkens, H. (1975)Voneida, T. J. and Sligar, C. (1976)Herwig, H. J. (1976)Herwig, H. J. (1976)Sligar, C. and Voneida, T. J. (1976)Durand, J. P. (1976)Wilkens, H. (1976)Erckens, W. and Weber, F. (1976)Yew, D. T. and Yoshihara, H. M. (1977)Zaccone, G. (1977)Wilkens, H. (1977)Kirby, R. F., Thompson, K. W. and Hubbs, C. (1977)Mitchell, R. W., Russell, W. H. and Elliott, W. R. (1977)Thines, G. and Weyers, M. (1978)Durand, J. P. (1978)Sadoglu, P. (1979)Wilkens, H., Peters, H. and Schemmel, C. (1979)Woodhead, A. D. and Achey, P. M. (1979)Durand, J. P. (1979)Schemmel, C. (1980)Weissert, R. (1980)Quinn, T. P. (1980)Wilkens, H. (1980)Wilkens, H. (1980)Campenhausen, C., Riess, I. and Weissert, R. (1981)Weissert, R. and Campenhausen, C. (1981)Herwig, H. J. (1981)Reddell, J. R. (1981)Lamprecht, G. and Weber, F. (1982)Jankowska, M. and Thines, G. (1982)Tabata, M. (1982)Erckens, W. and Martin, W. (1982)Erckens, W. and Martin, W. (1982)Rose, F. L. and Mitchell, R. W. (1982)Parzefall, J. (1983)Zilles, K., Tillmann, B. and Bennemann, R. (1983)Romero, A. (1983)Voneida, T. J. and Fish, S. E. (1984)Romero, A. (1984)Romero, A. (1984)Wilkens, H. (1984)Schuppa, M. (1984)Wilkens, H. (1985)Lamprecht, G. and Weber, F. (1985)Burchards, H., Dolle, A. and Parzefall, J. (1985)Teyke, T. (1985)Romero, A. (1985)Wilkens, H. (1986)Parzefall, J. (1986)Wilkens, H. and Huppop, K. (1986)Hassan, E. S. (1986)De Fraipont, M. (1986)Fraipont, M. (1986)Huppop, K. (1986)De Fraipont, M. and Thines, G. (1986)De Fraipont, M. and Thines, G. (1986)Romero, A. (1986)Wilkens, H. (1987)De Fraipont, M. (1987)De Fraipont, M. (1987)Huppop, K. (1987)Wilkens, H. (1988)Fricke, D. (1988)De Fraipont, M. (1988)Huppop, K. (1988)Teyke, T. (1988)Fack, H. and Wilkens, H. (1989)Langecker, T. G. (1989)Fricke, D. and Parzefall, J. (1989)Hassan, E. S. (1989)Huppop, K. (1989)Teyke, T. (1989)Langecker, T. G. (1990)Parzefall, J. and Fricke, D. (1990)Peters, N., Schmidt, W. and Fricke, D. (1990)Abdel-Latif, H., Hassan, E. S. and von Campenhausen, C. (1990)Yokoyama, R. and Yokoyama, S. (1990)Yokoyama, R and Yokoyama, S (1990)Teyke, T. (1990)Klimpel, B. and Parzefall, J. (1990)Campenhausen, C. (1991)Parzefall, J. and Fricke, D. (1991)Langecker, T. G., Wilkens, H. and Junge, P. (1991)Huppop, K. and Wilkens, H. (1991)Huppop, K. (1991)Riedel, G. and Krug, L. (1991)Lamprecht, G. and Weber, F. (1992)Wilkens, H. (1992)Parzefall, J. (1992)Parzefall, J. (1992)Langecker, T. G. and Longley, G. (1992)Wilkens, H. and Meyer, M. (1992)Hassan, E. S., Abdel-Latif, H. and Biebricher, R. (1992)De Fraipont, M. (1992)Parzefall, J. (1993)Langecker, T. G. (1993)Langecker, T. G., Schmale, H. and Wilkens, H. (1993)Langecker, T. G., Schmale, H. and Wilkens, H. (1993)Peters, N., Schacht, V., Schmidt, W. and Wilkens, H. (1993)Hoffman, S. and Hausberg, C. (1993)Teyke, T. and Schaerer, S. (1994)Borowsky, R. (1994)Langecker, T. G., Neumann, B., Hausberg, C. and Parzefall, J. (1995)Langecker, T. G., Wilkens, H. and Schmale, H. (1995)Yokoyama, S., Meany, A., Wilkens, H. and Yokoyama, R. (1995)Borowsky, R. (1996)Behrens, M., Langecker, T.G., Wilkens, H. and Schmale, H. (1997)Riedel, G. (1997)Riedel, G. and Krug, L. (1997)Borowsky, R. and Espinasa, L. (1997)Wilkens, H. (1998)Behrens, M, Wilkens, H and Schmale, H (1998)Contreras-Balderas, S. and Lozano-Vilano, M.D.L. (1998)Jeffery, WR and Martasian, DP (1998)Kullander, S. O. (1999)Baker, CF and Montgomery, J (1999)Yamamoto, Y. and Jeffery, W. R. (2000)Ford, D.C. (2000)Jeffery, W. R., Strickler, A.G., Guiney, S., Heyser, D.G. and Tomarev, S.I. (2000)Espinasa, L. and Borowsky, R. (2000)Strickler, A.G., Yamamoto, Y. and Jeffery, W. R. (2001)Jeffery, W. R. (2001)Boudriot, F and Reutter, K (2001)Espinasa, L. and Borowsky, R. (2001)Montgomery, J.C., Coombs, S. and Baker, C.F. (2001)Romero, A., Jeffery, W.R. and Yamamoto, Y. (2002)Berg, A. and Watson, G.M. (2002)Dowling, TE, Martasian, DP and Jeffery, WR (2002)Krejca, J. (2002)Strickler, AG, Famuditimi, K and Jeffery, WR (2002)Borowsky, RL and Wilkens, H (2002)Sarma, SSS, Lopez-Romulo, A and Nandini, S (2003)Wilkens, H. and Strecker, U. (2003)Contreras-Balderas, S, Almada-Villela, P, Lozano-Vilano, M de L and Garcia-Ramirez, ME (2003)Porter, M.L. and Crandall, K.A. (2003)Strecker, U. (2003)Strecker, U., Bernatchez, L. and Wilkens, H. (2003)McCauley, DW, Hixon, E and Jeffery, WR (2004)Protas ME, Hersey C, Kochanek D, Zhou Y, Wilkens H, Jeffery WR, Zon LI, Borowsky R, Tabin CJ. (2006)Protas, M., Conrad, M., Gross, J.B., Tabin, C. and Borowsky, R.L. (2007)Protas, M, Tabansky, I, Conrad, M, Gross, JB, Vidal, O, Tabin, C and Borowsky, RL (2008)Gross, J.B., Protas, M., Conrad, M., Scheid, P.E., Vidal, O., Jeffery, W.R., Tabin, C. and others (2008)Salin, K, Voituron, Y, Colson, C and Hervant, F (2008)Kowalko, J, Gross, JB, Protas, M, Borowsky, RL and Tabin, C (2009)Jeffery, WR (2009)Salin, K., Voituron, Y., Mourin, J. and Hervant, F. (2010)Esquivel-Bobadilla, S (2011)Bradic, M, Beerli, P and Borowsky, RL (2011)Kish, P.E., Bohnsack, B.L., Gallina, D., Kasprick, D.S. and Kahana, A. (2011)Salin, K, Voituron, Y, Mourin, J and Hervant, F (2011)Yamamoto, Y. and Jeffery, W.R. (2011)Kowalko, J, Rohner, N, Borowsky, RL and Tabin, C (2011)Gross, J.B. (2012)Bradic, M., Beerli, P., Garcia-de Leon, F. J., Esquivel-Bobadilla, S. and Borowsky, R. L. (2012)Protas, M. and Jeffery, W. R. (2012)Hervant, F. (2012)Wilkens, H. (2012)Trontelj, P. (2012)Dufton, M, Hall, BK and Franz-Odendaal, T. (2012)Idda, M.L., Bertolucci, C., Vallone, D., Gothilf, Y., Sánchez-Vázquez, F.J. and Foulkes N.S. (2012)Jeffery, W.R. (2012)Kowalko, J.E., Rohner, N., Rompani, S.B., Peterson, B.K., Linden, T.A., Yoshizawa, M., Kay, E.H., Weber, J., Hoekstra, H.E., Jeffery, W.R., Borowsky, R. and Tabin, C.J. (2013)Rohner, N., Jarosz, D.F., Kowalko, J.E., Yoshizawa, M., Jeffery, W.R., Borowsky, R.L., Lindquist, S. and Tabin, C.J. (2013)Rohner, N (2013)Kowalko, J., Rohner, N., Linden, T.A., Rompani S.B., Warren, W.C., Borowsky, R., Tabin, C.J., Jeffery, W.R. and Yoshizawa M. (2013)Bradic, M., Teotonio, H. and Borowsky, R. L. (2013)Gross, J.B., Furterer, A., Carlson, B.M. and Stahl, B.A. (2013)Beale, A., Guibal, C., Tamai, T. K., Klotz, L., Cowen, S., Peyric, E., Reynoso, V. H., Yamamoto, Y. and Whitmore, D. (2013)Stahl, B. A. and Gross, J. B. (2013)Beale, A. (2013)Stahl, AL (2013)Pazza, R (2013)Bibliowicz, J., Alie, A., Espinasa, L., Yoshizawa, M., Blin, M., Hinaux, H., Legendre, L., Pere, S. and Retaux, S. (2013)Atukorala, A. D. S., Hammer, C., Dufton, M. and Franz-Odendaal, T. A. (2013)Elliott, William R. (2013)Espinasa, L., Bartolo, N.D. and Newkirk, C.E. (2014)Atukorallaya, D. and Franz-Odendaal, T. (2014)McGaugh, S.E., Gross, J.B., Aken, B., Blin, M., Borowsky, R., Chalopin, D., Hinaux, H., Jeffery, W.R., Keene, A., Ma, L., Minx, P., Murphy, D., O'Quin, K.E., Retaux, S., Rohner, N., Searl, S.M., Stahl, B.A., Tabin, C., Volff, J.N., Yoshizawa M, Warren WC. (2014)Atukorala, A. D. S. and Franz-Odendaal, T. A. (2014)Moran, D., Softley, R. and Warrant, E.J. (2014)Elliott, W.R. (2014)Gross, J.B., Krutzler, A.J. and Carlson, B.M. (2014)Aspiras, A.C., Rohner, N., Martineau, B., Borowsky, R.L. and Tabin, C.J. (2015)Caballero-Hernandez, O., Hernandez-Patricio, M., Sigala-Regalado, I., Morales-Malacara, J. B. and Miranda-Anaya, M. (2015)Bradic, M, Rohner, N, Tabin, C and Borowsky, R. (2015)Stahl, Bethany A. and Gross, Joshua B. (2015)Rohner, N (2015)Stahl, B. A., Ma, L and Gross, J. B. (2015)Yoshizawa, Masato, Robinson, Beatriz G., Duboue, Erik R., Masek, Pavel, Jaggard, James B., O'Quin, Kelly E., Borowsky, Richard L., Jeffery, William R. and Keene, Alex C. (2015)Jaggard, J. B. (2015)Devos, Lucie, Alie, A. and Retaux, S (2015)Stemmer, M., Schuhmacher, L.-N., Foulkes, N.S., Bertolucci, C. and Wittbrodt, J. (2015)Silva, D. M. Z. A., Utsunomia, R., Pansonato-Alves, J.C., Oliveira, C. and Foresti, F. (2015)McGaugh, S. E. (2015)Dufton, Megan and Franz-Odendaal, Tamara A. (2015)Moran, D., Softley, R. and Warrant, E.J. (2015)Hinaux, H., Blin, M., Fumey, J., Legendre, L., Heuze, A., Casane, D. and Retaux, S. (2015)Fumey, J. (2015)Carlson, B.M., Onusko, S.W. and Gross, J.B. (2015)Carlson, B.M. and Gross, J.B. (2016)Beale, A. D. and Whitmore, D. (2016)Rohner, Nicolas (2016)Gross, J.B., Stahl, B.A., Powers, A.K. and Carlson, B.M. (2016)Aspiras, A., Tabin, C. and Rohner, N. (2016)Schmitter-Soto, JJ (2016)Keene, A.C., Yoshizawa, M. and McGaugh, S.E. (2016)Retaux, S., Alie, A., Blin, M., Devos, L., Elipot, Y. and Hinaux, H. (2016)Yoshizawa, M., Settle, A., Macaspac, C., Fernandes, V. Yoshida, M. and Keene, A. (2016)Casane, D. and Retaux, S. (2016)Foulkes, N. S., Whitmore, D., Vallone, D and Bertolucci, C. (2016)O'Quin, Kelly and McGaugh, Suzanne E. (2016)Atukorala, A. D. S. and Franz-Odendaal, Tamara A. (2016)Beale, A., Whitmore, D. and Moran, D. (2016)Jaggard, J. B., Robinson, B. G., Stahl, B, Oh, I, Masek, P, Yoshizawa, M and Keene, A. (2017)Krishnan, J and Rohner, N (2017)Alvarado, C.G. (2017)Stahl, B (2017)Lyon, A., Powers, A. K., Gross, J. B. and O'Quin, K. E. (2017)Stahl, B.A. and Gross, J.B. (2017)Gross, J. B. (2017)Kaplan, S.A., Powers, A.K. and Gross, J.B. (2017)Schmitter-Soto, JJ (2017)Jaggard, J. B. (2017)Wilkens, H. and Strecker, U. (2017)Hinaux, H, Recher, G, Alie, A., Legendre, L, Blin, M. and Retaux, S (2017)Yoshizawa, M (2017)Torres-Paz, J (2017)Fumey J, Hinaux H, Noirot C, Thermes C, Re´ taux S, Casane D. (2017)Carlson, B.M., Klingler, I.B., Meyer, B.J. and Gross, J.B. (2018)Klaassen, H., Wang, Y., Adamski, K., Rohner, N. and Kowalko, J.E. (2018)Rohner, N. (2018)Espinasa, L. (2018)Espinasa, L., Legendre, L., Fumey, J., Blin, M., Rétaux, S. and Espinasa, M. (2018)Mirande, J.M. (2018)Frøland Steindal, I.V., Beale, A.D., Yamamoto, Y. and Whitmore, D. (2018)Borowsky, R. (2018)Tabin, J.A., Aspiras, A., Martineau, B., Riddle, M., Kowalko, J. Borowsky, R. Rohner, N. and Tabin, C.J. (2018)Borowsky, R., Luk, A., He, X.J. and Kim, R.S. (2018)Retaux, S. (2018)Blin, M., Tine, E., Meister, L., Elipot, Y., Bibliowicz, J., Espinasa, L. and Rétaux, S. (2018)Riddle, M.R., Aspiras, A.C., Gaudenz, K., Peuß, R., Sung, J.Y., Martineau, B., Peavey, M., Box, A.C., Tabin, J.A., McGaugh, S., Borowsky, R., Tabin, C.J. and Rohner, N. (2018)Garita-Alvarado, C.A., Barluenga, M. and Ornelas-García, C.P. (2018)Rohner, N. (2018)Pazza, R., Dergam, J.A. and Kavalco, K.F. (2018)Powers, A.K., Kaplan, S.A., Boggs, T.E. and Gross, J. (2018)Jaggard, J.B., Stahl, B.A., Lloyd, E., Prober, D.A., Duboue, E.R. and Keene, A.C. (2018)Kopp, J., Avasthi, S. and Espinasa, L. (2018)Carlson, B.M. and Gross, J.B. (2018)Kling, J. (2018)Ojha, A. and Watve, M. (2018)Sears, C.R. and Gross, J.B. (2018)Chin, J.S.R., Gassant, C.E., Amaral, P.M., Lloyd, E., Stahl, B.A., Jaggard, J.B., Keene, A.C. and Duboue, E.R. (2018)Gore, A., Jeffery, W., Retaux, S. and Rohner, N. (2018)Stah, B.A., Sears, C.R., Ma, L., Perkins, M. and Gross, J.B. (2018)Gore, A.V., Rohner, N., Rétaux, S. and Jeffery, W.R. (2018)Powers, A.K., Boggs, T.E. and Gross, J.B. (2018)Stern, D.B and Crandall, K.A. (2018)Ma, L., Strickler, A.G., Parkhurst, A., Yoshizawa, M., Shi, J. and Jeffery, W.R. (2018)Alie, A., Devos, L., Torres-Paz, J., Prunier, L., Boulet, F., Blin, M., Elipot, Y. and Retaux, S. (2018)Xiong, S., Krishnan, J., Peuß, F. and Rohner, N. (2018)Ren, X.Y., Hamilton, N., Müller, F. and Yamamoto, Y. (2018)Yoshizawa, M., Settle, A., Hermosura, M.C., Tuttle, L.J., Cetraro, N., Passow, C.N. and McGaugh, S.E. (2018)Elliott, W.R. (2018)Fernandes, V.F.L., Macaspac, C., Lu, L. and Yoshizawa, M. (2018)Devitsina, G.V. and Golovkina, T.V. (2018)Fumey, J., Hinaux, H., Noirot, C., Thermes, C., Rétaux, S. and Casane, D. (2018)Gross, J.B., Weagley, J., Stahl, B.A., Ma, L., Espinasa, L. and McGaugh, S.E. (2018)Devi, A., Atukorala, S. and Franz-Odendaal, T.A. (2018)Torres-Paz,J., Hyacinthe, C., Pierre, C., Retaux, S. (2018)